The Absolute Insanity of MoltbookKDnuggets What the… AI agents arguing over memes? Sure, why not.
What the… AI agents arguing over memes? Sure, why not. Read More
Why Is My Code So Slow? A Guide to Py-Spy Python ProfilingTowards Data Science Stop guessing and start diagnosing performance issues using Py-Spy
The post Why Is My Code So Slow? A Guide to Py-Spy Python Profiling appeared first on Towards Data Science.
Stop guessing and start diagnosing performance issues using Py-Spy
The post Why Is My Code So Slow? A Guide to Py-Spy Python Profiling appeared first on Towards Data Science. Read More
Mechanistic Interpretability: Peeking Inside an LLMTowards Data Science Are the human-like cognitive abilities of LLMs real or fake? How does information travel through the neural network? Is there hidden knowledge inside an LLM?
The post Mechanistic Interpretability: Peeking Inside an LLM appeared first on Towards Data Science.
Are the human-like cognitive abilities of LLMs real or fake? How does information travel through the neural network? Is there hidden knowledge inside an LLM?
The post Mechanistic Interpretability: Peeking Inside an LLM appeared first on Towards Data Science. Read More
Tech Stack for Vibe Coding Modern ApplicationsKDnuggets Stop fighting AI. Use a tech stack AI understands and can build a paid SaaS within minutes.
Stop fighting AI. Use a tech stack AI understands and can build a paid SaaS within minutes. Read More
Cloud logs can be inconsistent or incomplete, creating blind spots as environments scale and change. Corelight shows how network-level telemetry provides reliable visibility when cloud logs fall short. […] Read More
Colonel Georgeo Xavier Pulikkathara, CISO at iMerit discusses the importance of fundamentals, continuous learning, and human ingenuity in the face of AI-driven cybersecurity evolution. Read More
Microsoft on Wednesday said it built a lightweight scanner that it said can detect backdoors in open-weight large language models (LLMs) and improve the overall trust in artificial intelligence (AI) systems. The tech giant’s AI Security team said the scanner leverages three observable signals that can be used to reliably flag the presence of backdoors […]
Since its launch in 2023, DragonForce has pushed a cartel model, emphasizing cooperation and coordination among ransomware gangs. Read More
Rank-and-Reason: Multi-Agent Collaboration Accelerates Zero-Shot Protein Mutation Predictioncs.AI updates on arXiv.org arXiv:2602.00197v2 Announce Type: cross
Abstract: Zero-shot mutation prediction is vital for low-resource protein engineering, yet existing protein language models (PLMs) often yield statistically confident results that ignore fundamental biophysical constraints. Currently, selecting candidates for wet-lab validation relies on manual expert auditing of PLM outputs, a process that is inefficient, subjective, and highly dependent on domain expertise. To address this, we propose Rank-and-Reason (VenusRAR), a two-stage agentic framework to automate this workflow and maximize expected wet-lab fitness. In the Rank-Stage, a Computational Expert and Virtual Biologist aggregate a context-aware multi-modal ensemble, establishing a new Spearman correlation record of 0.551 (vs. 0.518) on ProteinGym. In the Reason-Stage, an agentic Expert Panel employs chain-of-thought reasoning to audit candidates against geometric and structural constraints, improving the Top-5 Hit Rate by up to 367% on ProteinGym-DMS99. The wet-lab validation on Cas12i3 nuclease further confirms the framework’s efficacy, achieving a 46.7% positive rate and identifying two novel mutants with 4.23-fold and 5.05-fold activity improvements. Code and datasets are released on GitHub (https://github.com/ai4protein/VenusRAR/).
arXiv:2602.00197v2 Announce Type: cross
Abstract: Zero-shot mutation prediction is vital for low-resource protein engineering, yet existing protein language models (PLMs) often yield statistically confident results that ignore fundamental biophysical constraints. Currently, selecting candidates for wet-lab validation relies on manual expert auditing of PLM outputs, a process that is inefficient, subjective, and highly dependent on domain expertise. To address this, we propose Rank-and-Reason (VenusRAR), a two-stage agentic framework to automate this workflow and maximize expected wet-lab fitness. In the Rank-Stage, a Computational Expert and Virtual Biologist aggregate a context-aware multi-modal ensemble, establishing a new Spearman correlation record of 0.551 (vs. 0.518) on ProteinGym. In the Reason-Stage, an agentic Expert Panel employs chain-of-thought reasoning to audit candidates against geometric and structural constraints, improving the Top-5 Hit Rate by up to 367% on ProteinGym-DMS99. The wet-lab validation on Cas12i3 nuclease further confirms the framework’s efficacy, achieving a 46.7% positive rate and identifying two novel mutants with 4.23-fold and 5.05-fold activity improvements. Code and datasets are released on GitHub (https://github.com/ai4protein/VenusRAR/). Read More
How to Work Effectively with Frontend and Backend CodeTowards Data Science Learn how to be an effective full-stack engineer with Claude Code
The post How to Work Effectively with Frontend and Backend Code appeared first on Towards Data Science.
Learn how to be an effective full-stack engineer with Claude Code
The post How to Work Effectively with Frontend and Backend Code appeared first on Towards Data Science. Read More
